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Cervical Pre-cancer Treatment Failure Among Women Living With HIV in Zimbabwe

NCT07202936 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2025-10-02

No results posted yet for this study

Summary

The goal of this observational study is to improve cervical pre-cancer treatment outcomes among women living with HIV (WLWH), particularly in low and middle income countries (LMICs), by generating the evidence needed for post-treatment monitoring guidelines. The main questions it aims to answer are:

* What is the risk of disease recurrence/persistence after cervical pre-cancer treatment among women living with HIV in Zimbabwe?
* What is the predictive value of different human papillomavirus (HPV) and DNA methylation testing strategies for monitoring cervical disease recurrence/persistence after pre-cancer treatment?

Participants will have cervical biopsies taken for histological assessment and cervical samples for HPV genotyping and DNA methylation testing.

Researchers will follow all participating women every six months for 24 months to evaluate post-treatment monitoring and cervical disease outcomes.

Conditions

Sponsors & Collaborators

  • Krebsforschung Schweiz, Bern, Switzerland

    collaborator OTHER

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • National Institutes of Health (NIH)

    collaborator NIH

  • University of Bern

    lead OTHER

Principal Investigators

  • Margaret Pascoe, MD · Newlands Clinic Women's Health Centre

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-05-03
Primary Completion
2026-05-01
Completion
2027-04-01

Countries

  • Zimbabwe

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07202936 on ClinicalTrials.gov