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Intralesional Vitamin D Versus Intralesional Acyclovir in Plantar Warts

NCT07196670 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-09-29

No results posted yet for this study

Summary

The goal of this clinical trial is to compare intralesional vitamin D versus intralesional acyclovir in the treatment of plantar warts. It will also learn about the safety of both techniques. The main questions it aims to answer are:

which is more effective in the treatment of plantar warts? What medical problems do participants have when taking both? What is the recurrence rate in both treatment modalities? Participants will:• Sixty plantar warts patients will be included in this study.

* They will be randomly allocated into two groups: intralesional vitamin D group (group A) and intralesional Acyclovir group (group B). Patients will be blinded to their therapeutic arm.
* All patients will be subjected to the following:

1. Proper history taking and physical examination. Number and size of warts shall be noted.
2. Informed consent
3. Dermoscopic evaluation of the lesions by Fotofinder Medicam 800HD dermoscope
4. Digital photography of the lesions
* Group A:

The aqueous solution of vitamin D3 is used (Devarol S 200,000IU/2ml ) 0.6 ml (60,000 IU ) will be slowly injected into the base of the largest wart Injections will be repeated at 3 week intervals till resolution of warts or for a maximum of 4 sessions Any hyperkeratotic lesions will be pared before injection

• Group B: Acyclovir vial (250 mg) will be diluted with 3.5 ml saline to get approximately 70 mg/ml solution 0.1 ml will be slowly injected into the base of the largest wart Injections will be repeated at 3 week intervals till resolution of warts or for a maximum of 4 sessions Any hyperkeratotic lesion will be pared before injection

• Follow up:

After cessation of treatment, there will be one month follow up during which:

* Patient will be questioned about side effects
* Physical examination to check response and/or detect recurrence
* Photography in the same positions
* Size of the warts shall be noted
* Number of warts shall be noted

* Dermoscopic evaluation:

Patients will be examined with Fotofinder Medicam 800HD dermoscope Assessment of size and percentage of red dots and linear vessels per field At baseline, then after completion of treatment sessions and finally after 1 month from the last treatment session.

• Based on clinical, photographic and dermoscopic data, response will be graded by a blinded observer as follows: Complete response (100% disappearance of warts) Partial response (50-\<100% decrease in wart size) No response (\<50% decrease in wart size)

Conditions

  • Plantar Warts Treatment

Interventions

DRUG

intralesional vitamin D3 versus intralesional acyclovir

injecting intralesional vitamin D in group A versus injecting intralesional acyclovir in group B in treatment of plantar warts

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-30
Primary Completion
2025-12-31
Completion
2026-01-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07196670 on ClinicalTrials.gov