Product Responsiveness to Enhanced Bioavailability Curcumin Dietary Supplements in Adults

Summary

The goal of this clinical trial is to evaluate whether distinct formulations of bioavailable curcumin supplements can improve joint comfort in adults who experience self-reported discomfort. Participants will also receive a placebo during the study, but they will not know when they receive it.

The main questions it aims to answer are:

* Do participants report improved joint comfort after taking each curcumin-based supplement?
* Are there difference in quality-of-life scores or pain perceptions between the products?

Researchers will compare the effects of the different formulations of bioavailable curcumin supplements to see if one provides greater improvements in joint comfort and related outcomes.

Participants will:

* Wear a fitness tracker starting at the time of electronic consent to provide continuous data on physical activity, heart rate, and sleep
* Complete multiple blinded study periods involving different oral supplements, each separated by a washout period
* Take one supplement twice daily during each intervention period, with intervention periods lasting between approximately two and four weeks
* Complete washout periods of approximately one week between intervention periods
* Complete the validated RAND-36 quality-of-life questionnaire and other study-specific questionnaires adapted from commonly used pain and global impression scales to assess joint comfort, pain perception, and overall health
* Participate in a 30-day follow up period after the final supplement to complete final questionnaires and wearable data collection

The study is conducted remotely using the Alethios decentralized research platform.

Conditions

• Joint Discomfort
• Quality of Life (QOL)

Interventions

DIETARY_SUPPLEMENT

Supplement 2

A dietary supplement administered daily for 30 days. This supplement is being evaluated as part of a randomized, double-blind, crossover study to assess its effect on joint comfort. This product may be a placebo.

DIETARY_SUPPLEMENT

Supplement 3

A third dietary supplement administered daily for 30 days. This supplement is being evaluated as part of a randomized, double-blind, crossover study to assess its effect on joint comfort. This product may be a placebo.

DIETARY_SUPPLEMENT

Supplement 1

A dietary supplement administered daily for 14 days. This supplement is being evaluated as part of a randomized, double-blind, crossover study to assess its effect on joint comfort. This product may be a placebo.

Sponsors & Collaborators

• Ultra Botanica LLC

  lead OTHER

Principal Investigators

• Adam Payne, CEO, MBA · Ultra Botanica LLC

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

30 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-12-10

Primary Completion

2026-07-31

Completion

2026-08-31

Countries

• United States

Study Locations