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Polyphenol Metabolism and Personalized Nutrition in Menopause (PolyPause).

NCT07182370 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2025-09-19

No results posted yet for this study

Summary

The study aims to evaluate the role of the gut microbiome and phageome in explaining interindividual variability in the metabolic response to polyphenol-rich nutraceuticals among menopausal women. Insights from this research will support the development of personalized nutrition strategies to improve quality of life and reduce cardiovascular disease (CVD) risk during menopause.

Conditions

  • Menopause Related Conditions
  • Cardiovascular Risk

Interventions

DIETARY_SUPPLEMENT

Capsules containing plant extracts, including resveratrol, ellagic acid and isoflavones

Eight-week intake of three capsules per day, containing a total of 2.1 g of plant extracts (PPs), including 150 mg of resveratrol (found in grapes and red wine), 100 mg of ellagic acid (present in strawberries, walnuts, pomegranate, etc.), and 50 mg of the isoflavone daidzein, among others (found in soy, red clover, etc.).

DIETARY_SUPPLEMENT

Consumption of placebo

Daily intake of three capsules (2.1 g/day) of microcrystalline cellulose for eight weeks

Sponsors & Collaborators

  • Hospital Universitario Virgen de la Arrixaca

    collaborator OTHER

  • IMDEA Food

    collaborator OTHER

  • National Research Council, Spain

    lead OTHER_GOV

Principal Investigators

  • Juan C. Espín, PhD · Spanish National Research Council

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
45 Years
Max Age
57 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-15
Primary Completion
2025-07-01
Completion
2027-08-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07182370 on ClinicalTrials.gov