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Molecular Characterization and Outcomes of Aggressive B-Cell Lymphomas.

NCT07181785 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 555

Last updated 2025-09-18

No results posted yet for this study

Summary

This is a retrospective analysis of the presence of chromosomal rearrangements involving MYC, BCL2 and BCL6 genes by FISH in a retrospective, single-center series of large B-cell lymphomas, in order to allow a better classifications of these cases according to the current WHO 2017 classification. If this evaluation will be confirmed as a reliable method to reclassify in different groups the evaluated tumors, it can be subsequently routinely apply to indicate the best treatment approaches in this high-risk setting of patients with a significant impact on patients' morbidity and mortality, and also on the health system and related costs.

Conditions

  • Diffuse Large B Cell Lymphoma (DLBCL)

Interventions

COMBINATION_PRODUCT

Treatments: anthracycline-based combinations followed or not by involved-field radiotherapy

Anthracycline-based combinations followed or not by involved-field radiotherapy

Sponsors & Collaborators

  • Andrés José Maria Ferreri

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-12
Primary Completion
2023-07-12
Completion
2023-07-12

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07181785 on ClinicalTrials.gov