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Genicular Nerve Block in Chronic Knee Osteoarthritis

NCT07174167 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 81

Last updated 2025-11-28

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate whether genicular nerve block (GNB) is effective in reducing pain in patients with knee osteoarthritis. It will also assess the comparative efficacy of different injection protocols.

The main questions it aims to answer are:

Does genicular nerve block with corticosteroid and local anesthetic provide superior pain relief compared with local anesthetic alone or placebo?

Are there differences in clinical outcomes between the three treatment groups?

Researchers will compare three groups:

GNB with corticosteroid plus local anesthetic

GNB with local anesthetic alone

Sham procedure with saline (placebo control)

Participants will:

Receive the assigned injection protocol in accordance with their group

Be evaluated at baseline and scheduled follow-up visits for pain intensity and functional status

Report their pain scores and functional limitations using standardized assessment tools

Conditions

  • Gonarthrosis; Primary
  • Genicular Nerve Block
  • Gonarthritis

Interventions

DRUG

Sham injection

placebo injection using 6 mL of 0.9% saline to knee region other than genicular nerves

DRUG

Genicular nerve block with prilocaine

ultrasound guided genicular nerve block (GNB) injecting 6 mL of 2% prilocaine to the genicular nerves

DRUG

genicular nerve block with prilocaine and triamcinolone

ultrasound guided genicular nerve block (GNB) injecting 5 mL of 2% prilocaine in combination with 1 mL/40 mg of triamcinolone to the genicular nerves

Sponsors & Collaborators

  • Haydarpasa Numune Training and Research Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-01
Primary Completion
2024-02-10
Completion
2024-07-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07174167 on ClinicalTrials.gov