MedTrace Logo

Components of Mechanical Power on the Functional Lung in ARDS

NCT07171632 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 184

Last updated 2025-12-04

No results posted yet for this study

Summary

Mechanical power (MP) is a composite variable that integrates static and dynamic respiratory parameters and has been associated with ventilator-induced lung injury (VILI). MP is predominantly delivered to the reduced functional lung size, commonly referred to as the "baby lung" (BL). Functional lung size, in turn, is closely related to respiratory system compliance (Crs). Previous studies have demonstrated an association between MP normalized to compliance (MP/Crs) and mortality. Moreover, evidence suggests that VILI associated with MP/Crs results primarily from the combined effect of its components rather than from any single component in isolation.

The objective of this study is to evaluate both the overall and the relative contribution of each component of mechanical power, normalized to compliance (MP/Crs), to in-hospital mortality in patients with acute respiratory distress syndrome (ARDS).

Conditions

  • Respiratory Distress Syndrome (RDS)

Interventions

OTHER

monitoring of clinical and ventilatory variables

Monitoring clinical data

Sponsors & Collaborators

  • Universidad de la Republica

    collaborator OTHER

  • Ramos Mejía Hospital

    lead OTHER

Principal Investigators

  • Martin Angulo, PhD · Hospital de Clínicas "Dr. Manuel Quintela" Faculty of Medicine, Universidad de la República (Udelar) Montevideo, Uruguay

  • Antonella Gómez, MD · Hospital de Clínicas "Dr. Manuel Quintela" Faculty of Medicine, Universidad de la República (Udelar) Montevideo, Uruguay

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-12-01
Completion
2027-03-10

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07171632 on ClinicalTrials.gov