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Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III)

NCT07161869 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2025-09-09

No results posted yet for this study

Summary

In the POELH-II trial (Clinicaltrials.gov ID NCT05678218) patients with presumed resectable perihilar (pCCA), intrahepatic (iCCA) or mid-common bile duct (CBD) cholangiocarcinoma had the outcomes of their preoperative endoscopic ultrasound (EUS) registered. This EUS procedure was done systematically, targeting lymph nodes (LNs) with the aim to identify LN metastases preoperatively.

The goal of this follow-up observational cohort study (POELH-III) is to assess the yield of preoperative EUS, with an improved EUS approach. The EUS protocol as used in the POELH-II trial was improved based on preliminary results of the POELH-II trial. The main questions it aims to answer is:

\- The number of patients precluded from surgical work-up due to positive regional or extraregional LNs identified by EUS guided tissue acquisition

Conditions

  • Hilar Cholangiocarcinoma
  • Intrahepatic Cholangiocarcinoma (Icc)
  • Cholangiocarcinoma
  • Perihilar Cholangiocarcinoma
  • Common Bile Duct Neoplasms
  • Adenocarcinoma of Biliary Tract

Interventions

PROCEDURE

Registration of all findings during preoperative Endoscopic Ultrasound

Using the improved POELH-III EUS format

Sponsors & Collaborators

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2028-10-01
Completion
2028-11-01

Countries

  • Netherlands

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07161869 on ClinicalTrials.gov