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Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes

NCT07154875 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2025-09-05

No results posted yet for this study

Summary

This randomized controlled trial evaluates the effect of assisted hatching (AH) timing on embryo development and genetic outcomes in in vitro fertilization (IVF) cycles with preimplantation genetic testing for aneuploidy (PGT-A). Eligible patients undergoing IVF with PGT-A will have embryos randomized to receive assisted hatching either on Day-3 or Day-5 of culture, prior to trophectoderm biopsy. The primary outcome is the rate of aneuploid blastocysts. Secondary outcomes include blastocyst morphology, expansion stage, and the correlation between morphology and genetic results. The study aims to determine whether earlier or later assisted hatching affects embryo viability and the accuracy of genetic testing. The trial will provide evidence to optimize laboratory protocols in IVF centers.

Conditions

  • Infertility; In Vitro Fertilization; Embryo Development

Interventions

PROCEDURE

Assisted Hatching

Laser-assisted zona drilling performed either on Day-3 or Day-5 of culture, depending on randomization arm.

Sponsors & Collaborators

  • 16A Ha Dong General Hospital

    collaborator OTHER

  • Hoang Minh Ngan

    lead OTHER

Principal Investigators

  • Ngan M Hoang, MSc · Center for Reproductive Support, 16A Ha Dong General Hospital

  • Tao D Nguyen, MD, PhD, Professor · Center for Reproductive Support, 16A Ha Dong General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-14
Primary Completion
2026-12-14
Completion
2028-06-14

Countries

  • Vietnam

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07154875 on ClinicalTrials.gov