Efficacy and Safety of Shexiang Baoxin Pill(MUSKARDIA) in the Treatment of Acute Myocardial Infarction

Summary

This study aims to evaluate the value of Shexiang Baoxin Pill (MUSKARDIA) in patients with acute myocardial infarction (AMI) through a prospective, multicenter, pragmatic randomized controlled real-world study. It seeks to validate its efficacy in reducing cardiovascular event risk during the peri-PCI period, as well as its effects on cardiac function, quality of life , and relevant biomarkers. Through this research, we expect to provide higher-quality evidence for the application of SBP in AMI patients undergoing PCI, thereby further optimizing comprehensive treatment strategies for AMI.

Conditions

• Acute Myocardial Infarction (AMI)
• Percutaneous Coronary Intervention (PCI)

Interventions

DRUG

Aspirin

Patients in the Shexiang Baoxin Pill(MUSKARDI) group initiated treatment immediately after randomization. They received 2-4 pills of Shexiang Baoxin Pill preoperatively before PCI, followed by a maintenance dose of 2-4 pills orally three times daily (TID) with warm water for 12 months postoperatively, concurrently with standard guideline-directed therapy.

DRUG

Shexiang Baoxin Pill

Patients in the Shexiang Baoxin Pill group initiated treatment immediately after randomization. They received 2-4 pills of Shexiang Baoxin Pill preoperatively before PCI, followed by a maintenance dose of 2-4 pills orally three times daily (TID) with warm water for 12 months postoperatively, concurrently with standard guideline-directed therapy.

Sponsors & Collaborators

• Shanghai Zhongshan Hospital

  collaborator OTHER

• Huashan Hospital

  collaborator OTHER

• Shanghai 10th People's Hospital

  collaborator OTHER

• Shanghai 6th People's Hospital

  collaborator OTHER

• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Shanghai East Hospital

  collaborator OTHER

• Longhua Hospital

  collaborator OTHER

• Second Affiliated Hospital of Soochow University

  collaborator OTHER

• Affiliated Hospital of Jiangsu University

  collaborator OTHER

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• The First People's Hospital of Lianyungang

  collaborator OTHER

• Huai'an First People's Hospital

  collaborator OTHER

• Sir Run Run Shaw Hospital

  collaborator OTHER

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  collaborator OTHER

• First Affiliated Hospital of Ningbo University

  collaborator NETWORK

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• Qianfoshan Hospital

  collaborator OTHER

• Weihai Municipal Hospital

  collaborator OTHER

• Weifang People's Hospital

  collaborator OTHER

• Rizhao People's Hospital

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• Jining First People's Hospital

  collaborator OTHER

• Linyi People's Hospital

  collaborator OTHER

• Xiangya Hospital of Central South University

  collaborator OTHER

• Second Xiangya Hospital of Central South University

  collaborator OTHER

• Yueyang Central Hospital

  collaborator OTHER

• The First Affiliated Hospital of University of South China

  collaborator OTHER

• The Central Hospital of Shaoyang

  collaborator UNKNOWN

• The First People's Hospital of Changde City

  collaborator OTHER

• Wuxi People's Hospital

  collaborator OTHER

• Jinhua Central Hospital

  collaborator OTHER

• The Third Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Shuguang Hospital of Shanghai University of Traditional Chinese Medicine

  collaborator UNKNOWN

• Affiliated Hospital of Shandong University of Traditional Chinese Medicine

  collaborator OTHER

• ZhuZhou Central Hospital

  collaborator OTHER

• First People's Hospital of Chenzhou

  collaborator OTHER

• People's Hospital of Quzhou

  collaborator OTHER

• Xuzhou New Health Hospital

  collaborator UNKNOWN

• Taizhou Enze Medical Center Group

  collaborator OTHER

• Beijing Chao Yang Hospital

  collaborator OTHER

• Civil Aviation General Hospital

  collaborator OTHER

• Xuanwu Hospital, Beijing

  collaborator OTHER

• Beijing Friendship Hospital

  collaborator OTHER

• Peking University People's Hospital

  collaborator OTHER

• Beijing Electric Power Hospital

  collaborator OTHER

• Renmin Hospital of Wuhan University

  collaborator OTHER

• Wuhan No.1 Hospital

  collaborator OTHER

• Jingzhou Central Hospital

  collaborator OTHER

• The First Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• Ansteel Group General Hospital

  collaborator UNKNOWN

• General Hospital of Fuxin Mining Industry Group of Liaoning Health Industry Group

  collaborator UNKNOWN

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Huaihe Hospital of Henan University

  collaborator OTHER

• Zhoukou Central Hospital

  collaborator OTHER

• The First Affiliated Hospital of Henan University of Science and Technology

  collaborator OTHER

• First Affiliated Hospital of Nanyang Medical College

  collaborator OTHER

• Jiaozuo Second People's Hospital

  collaborator UNKNOWN

• Anyang Area Hospital of Puyang City

  collaborator UNKNOWN

• Shijiazhuang People's Hospital

  collaborator OTHER

• Cangzhou Central Hospital

  collaborator OTHER

• The First Hospital of Hebei Medical University

  collaborator OTHER

• Handan Central Hospital

  collaborator OTHER

• The People's Hospital of Langfang City

  collaborator UNKNOWN

• Xingtai Central Hospital

  collaborator UNKNOWN

• North China University of Science and Technology

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• the First Hospital of Anhui University of Science and Technology

  collaborator UNKNOWN

• Chaohu Hospital of Anhui Medical University

  collaborator OTHER

• Tongling People's Hospital

  collaborator OTHER_GOV

• Huang Shan People's Hospital

  collaborator OTHER

• Huaibei Miners General Hospital

  collaborator UNKNOWN

• The Second Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• Changzhi Medical College

  collaborator OTHER

• LinFen People's Hospital

  collaborator UNKNOWN

• Shanxi Cardiovascular Hospital

  collaborator OTHER

• Dazhou First People's Hospital

  collaborator UNKNOWN

• The Affiliated Hospital Of Southwest Medical University

  collaborator OTHER

• The Third Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• The First Affiliated Hospital of Guangdong Pharmaceutical University

  collaborator OTHER

• Yangchun People's Hospital

  collaborator UNKNOWN

• Shaoguan People's Hospital

  collaborator UNKNOWN

• Guilin People's Hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• Ji'an Central People's Hospital

  collaborator UNKNOWN

• Jiangxi Provincial People's Hopital

  collaborator OTHER

• People's Hospital of Chongqing

  collaborator OTHER

• Ankang Central Hospital

  collaborator OTHER

• Xiangyang Central Hospital

  collaborator OTHER

• Tianjin Third Central Hospital

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• The Second Affiliated Hospital of Hainan Medical University

  collaborator OTHER

• Lanzhou University Second Hospital

  collaborator OTHER

• Jilin Province People's Hospital

  collaborator UNKNOWN

• Inner Mongolia Autonomous Region People's Hospital

  collaborator UNKNOWN

• Yan'an Hospital of Kunming City

  collaborator UNKNOWN

• The People's Hospital of Jizhou District, Tianjin

  collaborator UNKNOWN

• The Southwest Hospital of Army Medical University

  collaborator UNKNOWN

• The First People's Hospital of Nanning

  collaborator UNKNOWN

• The People' s Hospital of Jiangmen

  collaborator UNKNOWN

• The second People's Hospital of Guiyang

  collaborator UNKNOWN

• The Third People's Hospital of Chengdu

  collaborator OTHER

• The Tirst People's Hospital of Mianyang

  collaborator UNKNOWN

• First Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• The First People's Hospital of Chu Zhou

  collaborator UNKNOWN

• Xuancheng people's hospital

  collaborator UNKNOWN

• Shanghai Hutchison Pharmaceuticals Limited

  lead INDUSTRY

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-09-01

Primary Completion

2028-12-31

Completion

2029-12-31

Countries

• China

Study Locations