PET/CT for Trop2 ADC Response Evaluation NSCLC
NCT07151898 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50
Last updated 2025-09-03
Summary
To evaluate whether serial 68Ga-MY6349 PET/CT imaging can serve as a noninvasive biomarker to predict the therapeutic efficacy of Trop2-targeted antibody-drug conjugate (Trop2-ADC) therapy in NSCLC patients.
Conditions
- NSCLC
- Trop2
- PET/CT
Interventions
- DIAGNOSTIC_TEST
-
68Ga-MY6349 PET/CT
Each participant will receive an intravenous injection of 68Ga-MY6349 and undergo PET/CT imaging at baseline and following two and/or four cycles of Trop2-ADC therapy.
Sponsors & Collaborators
-
The First Affiliated Hospital of Xiamen University
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-05-01
- Primary Completion
- 2027-05-01
- Completion
- 2027-05-01
Countries
- China
Study Locations
More Related Trials
-
Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC
NCT05800340 ·Status: RECRUITING ·Phase: PHASE2
-
The Effect of Toripalimab Plus Radiotherapy in Patients With Operable Stage II-IIIA (N+) Non Small Cell Lung Cancer
NCT05798845 ·Status: RECRUITING ·Phase: PHASE2
-
Induction Chemotherapy and Toripalimab Followed by Chemoradiotherapy for Large-volume Local Advanced NSCLC
NCT05888402 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients
NCT03925090 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study Evaluating Neoadjuvant Chemotherapy, Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade in Patients With Locally Advanced Non-Small Cell Lung Cancer
NCT07103395 ·Status: RECRUITING ·Phase: PHASE2
-
ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) in Thyroid Cancer
NCT06465017 ·Status: TERMINATED ·Phase: NA
-
Phase II Clinical Trial to Evaluate the Safety and Efficacy of TQB2450 Injection Combined With Anlotinib Capsule and Chemotherapy in the Treatment of Immunoresistant Advanced Non-small Cell Lung Cancer
NCT06141226 ·Status: RECRUITING ·Phase: PHASE2
-
Neoantigen-based Peptide Vaccine, PD-1 Inhibitor, and Radiotherapy for Advanced NSCLC Progressed After Second-line Treatment
NCT06751901 ·Status: RECRUITING ·Phase: PHASE2
-
A Single-arm Pilot Study of Tislelizumab Combined With Anlotinib in Patients With Advanced NSCLC With Driver-negative After Progression to Immunotherapy
NCT06356675 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
68Ga-FAPI-46 PET/CT for the Prediction of Clinical Response to Neoadjuvant Therapy in Nasopharyngeal Carcinoma Patients
NCT07139054 ·Status: COMPLETED
-
Programmed Death-1 (PD-1) Antibody Combined With Chemoradiotherapy in High-risk Recurrent Nasopharyngeal Carcinoma
NCT03930498 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Toripalimab Combined With Cryoablation for First-line Oligo-progression in Driver-negative Advanced NSCLC
NCT06127303 ·Status: RECRUITING ·Phase: PHASE2
-
Anti-PD-1 in Combination With Chemotherapy as First-Line Treatment to Lung Cancer
NCT03432598 ·Status: COMPLETED ·Phase: PHASE2
-
Study of TQB2450 Combined With Anlotinib in the Treatment of Mutation Positive Lung Cancer
NCT03983928 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Study of Autologous Cytotoxic T Lymphocyte Immunotherapy Combination With PD-1 Inhibitor in the Advanced NSCLC
NCT04193098 ·Status: UNKNOWN ·Phase: PHASE1
-
The Clinical Study of the Efficacy and Safety of Trop2-ADC Monotherapy or Combination Immunotherapy Strategy in the Treatment of Advanced Triple-negative Breast Cancer.
NCT06851299 ·Status: RECRUITING ·Phase: PHASE2
-
The Clinical Characteristics and Efficacy of Immunotherapy in First-line PD-L1-negative Advanced NSCLC Patients
NCT06496009 ·Status: NOT_YET_RECRUITING
-
Mechanism Study to Investigate Difference in Efficacy of Neoadjuvant Chemoimmunotherapy in Lung Squamous Cell Carcinoma
NCT06436040 ·Status: RECRUITING
-
A Study of TQB2450 Injection Plus Chemotherapy Followed by TQB2450 Plus Anlotinib Versus Tislelizumab Plus Chemotherapy Followed by Tislelizumab in the Treatment of First-line Non-squamous Non-small Cell Lung Cancer(NSCLC).
NCT05346952 ·Status: UNKNOWN ·Phase: PHASE3
-
Chemoradiotherapy Plus Anti-PD1 in Recurrent NPC: A Multicenter, Open-label, Randomised, Controlled, Phase III Trial
NCT05340491 ·Status: RECRUITING ·Phase: PHASE3
-
Adaptive Immunotherapy for Nasopharyngeal Carcinoma
NCT07154069 ·Status: RECRUITING ·Phase: PHASE3
-
Radiotherapy Combined With ICIs as Treatment for LA-NSCLC After Failing Induction Immunochemotherapy
NCT06031597 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Metronomic Capecitabine With or Without PD-1 Antibody as Adjuvant Therapy in High-risk Nasopharyngeal Carcinoma
NCT05342792 ·Status: RECRUITING ·Phase: PHASE3
-
IMM2520, a PD-L1 and CD47 Bispecific Antibody in Patients With Advanced Solid Tumors
NCT05780307 ·Status: RECRUITING ·Phase: PHASE1
-
Trametinib Plus Anlotinib in Non-G12C KRAS-Mutant NSCLC Patients
NCT04967079 ·Status: COMPLETED ·Phase: PHASE1