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Transcranial Pulse Stimulation for Alzheimer's Disease

NCT07143734 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-09-16

No results posted yet for this study

Summary

TPS is a non-invasive therapeutic modality that uses focused, low-energy pulse stimulation to stimulate tissue regeneration and reduce inflammation. In the context of neurological disorders, it is hypothesized that TPS can modulate neuronal activity, enhance synaptic plasticity, and reduce neuroinflammation. It is a relatively new application in neurological disease treatment and is still under intense investigation.

Conditions

  • Alzheimer Dementia (AD)

Interventions

DEVICE

transcranial pulse stimulation (TPS)

The TPS/Sham-TPS therapy is administered for the first two weeks, followed by additional sessions at some week intervals.

DEVICE

transcranial pulse stimulation (TPS-Sham)

Participants will undergo an identical procedure using a device that mimics the sound and sensation of active TPS but delivers no therapeutic energy pulses to the brain.

Sponsors & Collaborators

  • Asia Pacific Institute of Healthy ageing

    collaborator UNKNOWN

  • Associated medical supplies company limited

    collaborator UNKNOWN

  • Dongguan University of Technology

    collaborator UNKNOWN

  • SuZhou Engin Bio-medical Electronics.Co.Ltd.

    collaborator UNKNOWN

  • Chinese University of Hong Kong

    lead OTHER

Principal Investigators

  • Timothy Chi Yui Kwok, PhD · Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese UNiversity of Hong Kong

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-21
Primary Completion
2026-04-30
Completion
2026-06-30

Countries

  • Hong Kong

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07143734 on ClinicalTrials.gov