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Letrozole Step up Protocol for Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome

NCT07143682 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2025-12-16

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if drug letrozole in step up dose works better to treat anovulation in infertile women with polycystic ovary syndrome. It will also learn about the safety of drug letrozole in step up dose. The main Questions it aims to answer are:

* Does drug letrozole in step up dose result in better ovarian response?
* What medical problems do participants have when taking drug letrozole in step up dose? Researchers will compare drug letrozole step up dose to a standard low dose to see if the step up dose works to achieve better ovarian response.

Participants will:

* Take drug letrozole step up or standard low dose from day 2 of menstruation for 3 cycles
* Visit the clinic on day 12-16 of menstural cycle for checkups and tests
* Keep a diary of any untoward symptoms

Conditions

Interventions

DRUG

Letrozol step up dose

Tablet letrozole 2.5mg one, two, three, and four tablets once daily from 2nd/3rd day of the menstrual cycle for 4 days

DRUG

Conventional fixed dose letrozole

Tab letrozole 5mg once daily for 5 days started from the 2nd/3rd day of the menstrual cycle

Sponsors & Collaborators

  • Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-08
Primary Completion
2024-05-24
Completion
2024-06-30

Countries

  • Bangladesh

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07143682 on ClinicalTrials.gov