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Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

NCT07139899 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 5

Last updated 2025-11-20

No results posted yet for this study

Summary

In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.

Conditions

Interventions

COMBINATION_PRODUCT

Hyperpolarized Xenon 129

Pulmonary magnetic resonance imaging using hyperpolarized xenon-129 gas as an inhaled contrast agent

Sponsors & Collaborators

  • University of Kansas Medical Center

    collaborator OTHER

  • Polarean, Inc.

    collaborator INDUSTRY

  • Bastiaan Driehuys

    lead OTHER

Principal Investigators

  • David Mummy, PhD · Duke University

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-17
Primary Completion
2026-11-30
Completion
2027-09-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07139899 on ClinicalTrials.gov