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Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension

NCT07139756 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2025-08-24

No results posted yet for this study

Summary

Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.

Phase 2 primary objective: compare the brainstem responses to LBNP in patients with PD associated with OH to PD patients without OH using BOLD fMRI

Conditions

  • Parkinson Disease
  • Orthostatic Hypotension

Interventions

DIAGNOSTIC_TEST

Lower body negative pressure

LBNP is a technique that redistributes blood from the upper body to the dependent regions of the legs, thus reducing central venous pressure and venous return and thereby activating the sympathetic nervous system (SNS). The subject is placed in a cylindrical airtight tank, which is sealed at the level of the iliac crests, and sub-atmospheric pressure is produced using a vacuum pump. It can be used to characterize the cardiovascular responses to orthostatic stress

Sponsors & Collaborators

  • Ecole Polytechnique Fédérale de Lausanne

    collaborator OTHER

  • University Hospital, Geneva

    collaborator OTHER

  • Centre Hospitalier Universitaire Vaudois

    lead OTHER

Principal Investigators

  • Grégoire Wuerzner · CHUV

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2027-09-30
Completion
2028-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07139756 on ClinicalTrials.gov