European Registry Study on Lymphatic Interventions

Summary

This European multicenter observational study aims to evaluate the real-world use, timing, and outcomes of lymphatic interventions in patients with congenital heart disease and/or primary lymphatic disorders. The study will examine the effectiveness of diagnostic imaging and interventional techniques, such as lymphatic embolization, in improving clinical symptoms, biomarkers, and fluid-related complications. The central question is whether early diagnosis and targeted intervention can lead to clinically meaningful improvements and reduced need for reintervention. Data collected retrospectively and prospectively from participating centers will help identify predictors of outcome, assess disease severity, and inform standardized diagnostic and therapeutic pathways across Europe.

Conditions

• Lymphatic Disorders
• Plastic Bronchitis
• Protein Losing Enteropathy
• Chylothorax
• Lymphatic Abnormalities

Interventions

PROCEDURE

Lymphatic intervention

This intervention was made as part of their clinical treatment.

Sponsors & Collaborators

• UZ Leuven, Leuven, Belgium

  collaborator UNKNOWN

• UCL Bruxelles

  collaborator UNKNOWN

• Lund University Hospital

  collaborator OTHER

• University Hospital Schleswig-Holstein

  collaborator OTHER

• University Hospital, Aachen

  collaborator OTHER

• Deutsches Herzzentrum Muenchen

  collaborator OTHER

• Universitätsklinikum Erlangen, Erlangen, Bayern, Germany

  collaborator UNKNOWN

• UZ Gent, Belgium

  collaborator UNKNOWN

• Hospital for Children and Adolescents, University of Helsinki

  collaborator UNKNOWN

• Hospital Universitari Vall d'hebron Barcelona, Spain

  collaborator UNKNOWN

• Children's University Hospital, Ireland

  collaborator OTHER

• Evelina London Children's Hospital

  collaborator UNKNOWN

• Guy's and St Thomas' NHS Foundation Trust

  collaborator OTHER

• Bambin Gesù Hospital IRCCS, Rome, Italy

  collaborator UNKNOWN

• Rigshospitalet, Denmark

  lead OTHER

Principal Investigators

• Vibeke E Hjortdal, Professor · Rigshospitalet, Denmark

• Michael Rahbek Schmidt, Ass. professor, PhD, DMSc · Rigshospitalet, Denmark

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-02-01

Primary Completion

2030-03-31

Completion

2030-03-31

Countries

• Denmark

Study Locations