Chest dRain rEmoval intrAoperatively afTer thoracOscopic Wedge Resection

Summary

Chest drain is used routinely after lung surgery. Despite preliminary studies demonstrate the feasibility and safety of intraoperative chest drain removal, these are either retrospective or mainly concerning benign disease.

Hypothesis: Participants treated without post-operative chest tube after thoracoscopic wedge resection have less pain, reduced opioid usage without increasing postoperative complications than participants treated with standard post-operative chest tube, and could possibly be discharged earlier.

Conditions

• Lung Neoplasms
• Lung Surgery
• Enhanced Recovery After Surgery
• Fast-track Surgery
• Pain
• Opioid Use
• Remission

Interventions

PROCEDURE

Intraoperative air leak test

A standard 28 Fr chest drain is inserted through the anterior port hole with all port holes closed. With the tip of the chest tube below water, the pleura is emptied from air during continuous ventilation of the lungs. An air leak after 5 minutes of ventilation indicates a negative sealing test, whereas a cessation of air leak within 5 minutes indicates a positive sealing test.

PROCEDURE

Intraoperative chest drain removal

Chest drain is removed intraoperatively.

PROCEDURE

Standard chest drain placement

Chest drain is left in pleura.

Sponsors & Collaborators

• Aarhus University Hospital

  collaborator OTHER

• Rigshospitalet, Denmark

  lead OTHER

Principal Investigators

• René H Petersen, MD, PhD · Rigshospitalet, Denmark

• Thomas D Christensen, MD, PhD · Aarhus University Hospital

• Bo L Holbek, MD, PhD · Rigshospitalet, Denmark

• Morten Bendixen, MD, PhD · Aarhus University Hospital

• Jonas J Rasmussen, MD · Aarhus University Hospital

• Henrik Kehlet, MD, PhD · Rigshospitalet, Denmark

• Henrik J Hansen, MD · Rigshospitalet, Denmark

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-05-04

Primary Completion

2024-03-17

Completion

2024-03-17

Countries

• Denmark

Study Locations