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Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve

NCT07124260 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-08-26

No results posted yet for this study

Summary

The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue coating microbiota, gut microbiota, and their interrelationships in DOR patients. The main question it aims to answer is:

Whether there are significant differences in tongue manifestations, tongue coating microbiota, and gut microbiota characteristics between DOR patients and healthy populations; Whether associations exist between tongue coating microbiota and gut microbiota in DOR patients; Whether the pathogenesis of DOR may influence estrogen metabolism through alterations in oral and gut microbiota.

Conditions

  • Diminished Ovarian Reserve

Interventions

DIAGNOSTIC_TEST

gut microbiota

Fresh fecal samples were collected from patients during the non-menstrual period and subjected to 16S rDNA sequencing.

DIAGNOSTIC_TEST

tongue coating microbiota

Tongue coating samples were collected under fasting conditions between 6:00-9:00 AM on the same day as fecal specimen collection and subjected to 16S rDNA sequencing.

DIAGNOSTIC_TEST

tongue picture

Tongue images were captured under fasting conditions between 6:00-9:00 AM on the same morning as fecal specimen collection.

Sponsors & Collaborators

  • Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University

    lead OTHER

Eligibility

Min Age
20 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-28
Primary Completion
2025-12-01
Completion
2025-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07124260 on ClinicalTrials.gov