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Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment

NCT07116330 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 420

Last updated 2026-03-03

No results posted yet for this study

Summary

A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown.

The investigators aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. In a cluster project the investigators assess the effect of vascular risk factor screening in an observational study as well as a cohort study.

The project has two interlinked components: a prospective single group study, in which risk factor assessment is performed and subsequent management is followed for one year; and a register-based cohort study examining the long-term effects of the intervention on a system level.

Conditions

Interventions

OTHER

Vascuar risk factor screening (blood pressure, medical history, BMI, laboratory tests)

The vascular risk assessment is outlined below, there may be slight variations according to local routines. Overall, the screening should include: Family history of vascular disease Tests/examinations (order or obtain from medical records \[past 3 months\]) Weight Height Waist circumference 12-lead ECG Resting and standing blood pressure Total cholesterol HDL cholesterol LDL cholesterol HbA1c High sensitivity CRP Serum creatinine Urine albumin-to-creatinine ratio Medical history Atherosclerotic cardiovascular disease Atrial fibrillation Congestive heart failure Diabetes mellitus Hypertension Kidney disease Life-style risk factors (smoking, exercis

Sponsors & Collaborators

  • Sodra Alvsborgs Hospital

    collaborator OTHER

  • Skane University Hospital

    collaborator OTHER

  • Danderyd Hospital

    collaborator OTHER

  • Uppsala University Hospital

    collaborator OTHER

  • Sahlgrenska University Hospital

    lead OTHER

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2027-12-31
Completion
2035-06-30

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07116330 on ClinicalTrials.gov