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Effect of Combined Probiotics and Vitamin D on Symptoms of Allergic Rhinitis

NCT07115342 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-08-14

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if taking probiotics, vitamin D, or both together can help lower symptoms of allergic rhinitis (AR) and improve quality of life in adults. Allergic rhinitis is a condition that causes sneezing, nasal congestion, and itchy or watery eyes.

The main questions this study aims to answer are:

• Do these supplements improve the quality of life for people with AR?

Researchers will compare four groups:

* People taking probiotics and vitamin D
* People receiving standard treatment only (control group)

Participants will:

* Take a probiotic capsule daily and/or a vitamin D tablet (based on blood levels) for 12 weeks
* Continue standard allergic rhinitis treatment (like antihistamines or nasal sprays)
* Visit the clinic for checkups and lab tests
* Complete surveys about their symptoms and quality of life

This study will help researchers understand if adding probiotics and/or vitamin D to standard care can help people with allergic rhinitis feel better.

Conditions

  • Allergic Rhinitis
  • Allergic Rhinitis (AR)

Interventions

DRUG

Standard Allergic Rhinitis Treatment

Participants will receive standard-of-care treatment for allergic rhinitis, including oral antihistamines and/or intranasal corticosteroids, according to current clinical guidelines. No additional supplementation will be provided in the control group. This arm serves as the comparator for evaluating the effects of probiotic and vitamin D supplementation

DIETARY_SUPPLEMENT

Combined Vitamin D and Probiotics Supplementation

Participants in this group will receive a combination therapy of Vitamin D3 plus a daily oral probiotic capsule containing a standardized blend of Lactobacillus and Bifidobacterium species. Both supplements will be administered once daily for 12 weeks. This intervention aims to assess the synergistic effect of vitamin D and probiotics on immune response and symptom relief in allergic rhinitis.

Sponsors & Collaborators

  • Tanta University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-01
Primary Completion
2025-10-30
Completion
2025-11-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07115342 on ClinicalTrials.gov