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Effects of Broccoli Sprout Extract on Allergy Rhinitis

NCT02885025 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 47

Last updated 2020-06-19

Study results available
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Summary

Allergic rhinitis is a common illness suffered among US Veterans. There are medications that help relieve allergy symptoms, including nasal steroid sprays and antihistamines. Some patients have increase symptoms with exposure to their trigger, such as a grasses when combined with pollution due to oxidative stress from pollution. In this study, patients with allergic rhinitis to grass will be given broccoli sprout extract that contains an antioxidant sulforaphane do see if there is beneficial effect in these patients.

Conditions

  • Rhinitis,Allergic

Interventions

DIETARY_SUPPLEMENT

Broccoli Sprout Extract

Broccoli Sprout Extract contains the antioxidant Sulforaphane which is the active ingredient being studies.

DRUG

fluticasone nasal

fluticasone is a nasal steroid that is currently approved for treatment of allergic rhinitis.

DIETARY_SUPPLEMENT

broccoli sprout extract placebo

a tablet similar to the actual broccoli sprout extract though without BSE.

DRUG

normal saline nasal spray

normal saline to replace nasal fluticasone in specific arms of the study

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Zhaoping Li, MD · VA Greater Los Angeles Healthcare System, West Los Angeles, CA

  • Joseph Stephen Yusin, MD · VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-10-01
Primary Completion
2019-03-12
Completion
2019-03-12
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02885025 on ClinicalTrials.gov