Effectiveness of Interventions for Improving HPV Vaccination Cover

Summary

Research Problem and Question: The development of prophylactic vaccines against the human papillomavirus (HPV) marks a major scientific and technological advance in the fight against cervical cancer. However, translating the efficacy of these results into effectiveness in terms of reducing the disease burden in the target population requires the vaccine to be delivered within comprehensive public health programs. HPV vaccination and cervical cancer screening have not been adequately integrated. While studies have evaluated the effectiveness of different educational strategies aimed at increasing HPV vaccination acceptability and coverage, the evidence is still heterogeneous and limited. In this regard, a systematic review emphasizes that the shortcomings of the available research lie in three key aspects: a lack of coordination with the setting where the intervention is delivered, errors in selecting the most appropriate strategy, and inaccuracies in study design and conduct (risk of bias). In Colombia, there are no recent data from the same time period or by regional context that have evaluated the effectiveness of two training interventions aimed at increasing HPV vaccine coverage.

General Objective To evaluate the effectiveness of two training interventions aimed at increasing HPV vaccine coverage in four regions of Colombia.

Materials and methods Pragmatic cluster randomized controlled trial.

The study hypotheses are:

H1: The use of educational interventions does not increase HPV vaccine coverage.

H2: The use of educational interventions increases HPV vaccine coverage.

Conditions

• Health Adults
• Teenager

Interventions

BEHAVIORAL

Instructions, advices

A first moment: informed conversation and exploration of myths and realities with the aim of exploring the perceptions and attitudes of participating children and adolescents towards the vaccine against HPV-associated cancers through an open and reflective dialogue; a second moment with the presentation of a testimonial video and reflection with the aim of learning from the experiences of others, finding inspiration and motivation in their stories, and feeling connected with other people; and a third moment of 360° feedback with the aim of receiving final information about HPV, HPV-associated cancers, and the importance of vaccination.

OTHER

No instructions

No instructions for vaccination

Sponsors & Collaborators

• Universidad de Cartagena

  collaborator OTHER

• Instituto Nacional de Cancerologia, Columbia

  lead OTHER_GOV

Principal Investigators

• Alba Cómbita, Phd · Instituto Nacional de Cancerologia, Columbia

• Juliana Rodriguez, Ginecologisth oncologist · Instituto Nacional de Cancerologia, Columbia

• Carolina Wiesner, Director · Instituto Nacional de Cancerologia, Columbia

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

9 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-01-01

Primary Completion

2025-04-30

Completion

2025-07-31

Countries

• Colombia