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Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

NCT07108166 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 290

Last updated 2026-05-07

No results posted yet for this study

Summary

The purpose of this randomized study is to demonstrate direct clinical benefit, i.e., observed benefits in how humans with COPD feel in terms of symptoms (e.g., cough frequency, shortness of breath, and other respiratory symptoms) and function (e.g., lung function, and six-minute walking test \[6MWT\]) after switching to THS compared to continuing to smoking cigarettes.

Conditions

  • COPD
  • Smoking
  • Tobacco Use

Interventions

OTHER

Cigarette

COPD patients will continue to smoke their cigarettes ad libitum, with no brand restrictions.

OTHER

THS

COPD patients will switch from cigarette smoking to ad libitum THS use, with no flavor variant restrictions.

Sponsors & Collaborators

  • Philip Morris Products S.A.

    lead INDUSTRY

Principal Investigators

  • Xavier Jaumont, MD · Philip Morris Products S.A.

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-02
Primary Completion
2026-08-31
Completion
2026-11-30

Countries

  • United States
  • Bulgaria
  • Czechia
  • Germany
  • Japan
  • Poland
  • Romania
  • Slovakia
  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07108166 on ClinicalTrials.gov