An Exploratory Study on NK Cell-assisted Prevention of Bone Marrow Suppression During Chemotherapy for Ovarian Cancer
NCT07096583 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2025-07-31
Summary
To evaluate the remission effect and safety of intravenous injection of METR-NK cells as adjuvant therapy on bone marrow suppression in patients with ovarian cancer after chemotherapy
Conditions
- Ovary Cancer
Interventions
- BIOLOGICAL
-
METR-NK cell(metabolic remodeling nature killer cells)
100 mL METR-NK cells were diluted in 500 mL 0.9% sodium chloride normal saline at 37℃, and the infusion volume of METR-NK cells was not less than 2×107 cells/kg for 1 day as a course of treatment, and the infusion time was maintained for 30 minutes on the 10th day before chemotherapy.
Sponsors & Collaborators
-
Anhui Kecheng intelligent health technology Co., LTD
collaborator UNKNOWN -
Anhui Provincial Cancer Hospital
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-07-07
- Primary Completion
- 2026-07-30
- Completion
- 2027-07-30
Countries
- China
Study Locations
More Related Trials
-
Microtransplantation for Ovarian Cancer
NCT05095558 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Intraperitoneal Infusion of ex Vivo-cultured Allogeneic NK Cells in Recurrent Ovarian Carcinoma Patients
NCT03539406 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of ZW171 in Participants With Advanced or Metastatic Mesothelin-expressing Cancers
NCT06523803 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase 2, Open-label, Single-arm Study Of Autologous M-CENK Adoptive Cell Therapy And N-803 (IL-15 Superagonist) In Combination With Gemcitabine In Participants With Recurrent Platinum-Resistant High-Grade Ovarian Cancer
NCT06710288 ·Status: RECRUITING ·Phase: PHASE2
-
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
NCT06586957 ·Status: RECRUITING ·Phase: PHASE1
-
Study of LD013 in Subjects With Refractory or Relapsed Mesothelin -Positive Ovarian Cancer
NCT05372692 ·Status: COMPLETED ·Phase: NA
-
Neoadjuvant RC48 Plus Carboplatin for HER2-expressing Advanced Ovarian Cancer
NCT06574763 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Dendritic Cell Vaccination With Standard Postoperative Chemotherapy for the Treatment of Adult Ovarian Cancer
NCT05270720 ·Status: UNKNOWN ·Phase: PHASE1
-
Study to Evaluate the Safety and Efficacy of NKTR-102 in Patients With Metastatic or Locally Advanced Ovarian Cancer
NCT00806156 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Effect of HER2 Activation on rhuMAb 2C4 (Pertuzumab) in Subjects With Advanced Ovarian Cancer
NCT00058552 ·Status: COMPLETED ·Phase: PHASE2
-
NKG2D CAR-NK & Ovarian Cancer
NCT05776355 ·Status: UNKNOWN ·Phase: NA
-
OveRcoming immunosupprEssion aNd rebAlancing the Immune reSponSe in ovAriaN CancEr Study
NCT06611072 ·Status: RECRUITING ·Phase: NA
-
Survival Effect of Hepato-celiac Lymphadenectomy In Primary or Relapsed Ovarian Cancer
NCT05236686 ·Status: RECRUITING ·Phase: NA
-
Chemotherapy Supported by Autologous Hematopoietic Stem Cells
NCT05401162 ·Status: RECRUITING ·Phase: NA
-
Intraperitoneal Chemotherapy in Recurrent Ovarian Cancer
NCT06535334 ·Status: NOT_YET_RECRUITING
-
An Exploratory Clinical Study of Statins for Improving Chemotherapy and Maintenance in Patients With Ovarian Cancer
NCT06468254 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of AK104 (PD-1/CTLA-4 Bispecial Antibody) Combined With Chemotherapy for Neoadjuvant Treatment of Advanced Ovarian Cancer
NCT06542549 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Infusion of Autologous T Cells Engineered to Target FSH Receptor in Recurrent Ovarian Cancer
NCT05316129 ·Status: RECRUITING ·Phase: PHASE1
-
An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer
NCT06560112 ·Status: RECRUITING ·Phase: PHASE2
-
Genomic Profiling of the Residual Disease of Advanced-stage Ovarian Cancer After Neoadjuvant Chemotherapy
NCT03491033 ·Status: COMPLETED
-
Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Persistent or Platinum Refractory Stage III or IV Ovarian Cancer
NCT00003080 ·Status: COMPLETED ·Phase: PHASE1
-
Primary Tumor Harvest for the Purpose of Possible Use in a Future Clinical Trial in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Cancer
NCT00801320 ·Status: COMPLETED ·Phase: NA
-
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma
NCT03394027 ·Status: COMPLETED ·Phase: PHASE2
-
Blood Collection From People With Ovarian Cancer
NCT02063464 ·Status: COMPLETED
-
Diagnosis of Epithelial Ovarian Cancer Using Ovarian Cancer Score (OCS) Test
NCT06366997 ·Status: COMPLETED