MedTrace Logo

Blood Collection From People With Ovarian Cancer

NCT02063464 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 85

Last updated 2023-05-24

No results posted yet for this study

Summary

Background:

* Monocytes are a type of white blood cell found in human blood. They help the immune system. Researchers have found that monocytes taken from the blood of healthy people can kill tumor cells. Now they want to know if monocytes taken from the blood of people with ovarian cancer can kill tumor cells.
* In addition, native host anti-tumor cell mediated immune mechanisms may play a role in clinical outcome of epithelial ovarian cancer; data indicate that the presence of intra-tumoral CD3+ T-cells was shown to prognosticate improved outcome in advanced ovarian cancer. Furthermore, non-cellular components in the blood, such as exosomes, may influence outcome.

Objective:

\- To see if monocytes taken from the blood of people with ovarian cancer can kill tumor cells.

Eligibility:

\- Women 18 years and older with ovarian cancer.

Design:

* Participants will be screened with:
* Medical history and physical exam.
* Blood tests.
* CT scan of the chest, abdomen, and pelvis and/or an MRI. For these scans, they will lie in a machine that takes pictures of their body.
* A small amount of blood (two tubes) will be collected by needle during one visit.

Conditions

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    lead NIH

Principal Investigators

  • Christina M Annunziata, M.D. · National Cancer Institute (NCI)

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-03-10
Primary Completion
2016-03-14
Completion
2016-11-16

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02063464 on ClinicalTrials.gov