Deep Learning Model Predicts Pathological Complete Response of Esophageal Squamous Cell Carcinoma Following Neoadjuvant Immunochemotherapy
NCT07088354 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300
Last updated 2025-07-28
Summary
This study aims to develop and validate a deep learning model to predict pathological complete response (pCR) in patients with esophageal squamous cell carcinoma who have undergone neoadjuvant immunochemotherapy. Clinical, imaging, and pathological data from previously treated patients will be collected and analyzed. The model is expected to assist in predicting treatment outcomes and guide personalized therapeutic strategies.
Conditions
- Esophageal Squamous Cell Carcinoma
- Neoadjuvant Immunochemotherapy
- Pathological Complete Response
- Deep Learning
Interventions
- DIAGNOSTIC_TEST
-
The high-throughput extraction of large amounts of quantitative image features from medical images
The high-throughput extraction of large amounts of quantitative image features from medical images
Sponsors & Collaborators
-
Tongji Hospital
lead OTHER
Principal Investigators
-
Yangkai Li, MD, PhD · Tongji Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-03-01
- Primary Completion
- 2026-06-01
- Completion
- 2026-12-01
Countries
- China
Study Locations
More Related Trials
-
Neoadjuvant Immunotherapy (PD-1 / PD-L1) Combined With Chemotherapy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma: a Single Center, Prospective, Open, One Arm Exploratory Clinical Study
NCT05028231 ·Status: UNKNOWN
-
Development and Application of AI-Based Therapeutic Strategies for Esophageal Cancer Integrating Multimodal Imaging and Digital Pathology
NCT07203690 ·Status: NOT_YET_RECRUITING
-
Response Prediction to Neoadjuvant Chemoradiation in Esophageal Cancer Using Artificial Intelligence & Machine Learning
NCT04489368 ·Status: UNKNOWN
-
Accurate Diagnosis of the Invasion Depth in ESCC by a Deep Neural Network Analysis of NBI Endoscopy Data
NCT06252974 ·Status: NOT_YET_RECRUITING
-
Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma
NCT06446726 ·Status: RECRUITING ·Phase: PHASE2
-
An Observational Study on the Safety and Efficacy of Immunotherapy Combined With Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
NCT07080437 ·Status: RECRUITING
-
Machine Learning to Predict Lymph Node Metastasis in T1 Esophageal Squamous Cell Carcinoma
NCT06256185 ·Status: COMPLETED ·Phase: NA
-
Concurrent Radiotherapy Following Induction Chemoimmunotherapy for Locally Advanced Esophageal Cancer
NCT07015489 ·Status: COMPLETED ·Phase: PHASE2
-
Prognostic Analysis of Esophageal Cancer with Complete Pathological Response After Neoadjuvant Therapy
NCT06889402 ·Status: NOT_YET_RECRUITING
-
Neoadjuvant Radiochemotherapy Combined With Cadonilizumab for Local Advanced Esophageal Squamous Cell Cancer
NCT07016724 ·Status: RECRUITING ·Phase: PHASE2
-
Biomarkers and Functional Imaging in Predicting Response of Esophageal Cancer
NCT03029793 ·Status: UNKNOWN
-
a Neo-adjuvant Chemotherapy Immunotherapy in Resectable ESCC Study
NCT06472635 ·Status: ACTIVE_NOT_RECRUITING
-
Adjuvant Immunotherapy for Esophageal Squamous Cell Carcinoma
NCT07067450 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Neoadjuvant Immunochemotherapy and Chemoradiotherapy Followed by Surgery for Advanced Esophageal Squamous Cell Carcinoma
NCT06764355 ·Status: RECRUITING ·Phase: PHASE2
-
AI-assisted Endoscopic Ultrasound Grading of Early Esophageal Cancer Invasion Depth: A Multicenter, Prospective, Randomized Cohort Study
NCT07251114 ·Status: RECRUITING ·Phase: NA
-
Optimizing Neoadjuvant Treatment Regimens for Locally Advanced Esophageal Squamous Cell Carcinoma
NCT06907602 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Tislelizumab Combined With Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma Followed by CRT or Surgery
NCT07046221 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
The PET-CT Predicting Response to Immunochemotherapy in Esophageal Cancer
NCT05615103 ·Status: UNKNOWN
-
Autologous Tumor Tissue Antigen-sensitized DC-CIK Cells Combined With Chemotherapy for Esophageal Cancer
NCT02644863 ·Status: UNKNOWN ·Phase: PHASE2
-
Multi-institutional Analysis of Survival and Recurrence Patterns of Different Pathological Regression Types After Neoadjuvant Chemoradiotherapy or Radiotherapy for Esophageal Squamous Cell Carcinoma
NCT06241079 ·Status: COMPLETED
-
Neoadjuvant Immunotherapy Combined With Chemotherapy in Patients With Locally Advanced ESCC
NCT05807542 ·Status: COMPLETED ·Phase: PHASE2
-
Risk Factors of Relapse in Esophageal Squamous Cell Cancers Who Achieve PCR to Neoadjuvant Chemoradiotherapy
NCT06061263 ·Status: UNKNOWN
-
Neoadjuvant Camrelizumab With Palbociclib for Resectable Esophageal Squamous Cell Carcinomas
NCT06654297 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Neoadjuvant Chemoradiotherapy Combined With Perioperative Toripalimab in Locally Advanced Esophageal Cancer
NCT04437212 ·Status: UNKNOWN ·Phase: PHASE2
-
Ivonescimab Plus Short-Course Hypofractionated Radiotherapy as Second-Line Therapy for Esophageal Squamous Cell Carcinoma
NCT07188103 ·Status: RECRUITING ·Phase: PHASE2