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Methamphetamine Cue-reactivity

NCT07086014 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2025-07-25

No results posted yet for this study

Summary

In this observational cohort study, the researchers propose to first identify a psychophysiological marker of methamphetamine cue-reactivity and its incubation with abstinence from methamphetamine use (MUD) and examine group-differences between men who have sex with men (MSM) and non-MSM MUD.

The primary objective is to identify psychophysiological markers of methamphetamine (MA) cue-reactivity and its abstinence incubation. The secondary objective is to examine group-differences in methamphetamine use disorder (MUD) individuals between homosexual men (MSM) and heterosexual men (non-MSM). The primary endpoint is to assess incubation of cue-reactivity longitudinally with its reduction in cognitive reappraisal, and the secondary endpoint is to examine the impact of cognitive reappraisal on clinical outcomes of methamphetamine use disorder (MUD) in homosexual men (MSM).

2-year long study. Screening and enrollment will be done at different locations of the Addiction Institute of Mount Sinai. The EEG session will be done at Icahn School of Medicine at Mount Sinai. Participation in the research study will be for a single EEG session.

Conditions

  • Methamphetamine Use Disorder

Interventions

BEHAVIORAL

Cognitive Reappraisal

an emotion-regulation strategy while being asked to complete cognitive tasks.

Sponsors & Collaborators

Principal Investigators

  • Muhammad A Parvaz, PhD · Icahn School of Medicine at Mount Sinai

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-19
Primary Completion
2025-08-30
Completion
2025-08-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07086014 on ClinicalTrials.gov