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Comparison of Outcomes of Management of Bowel Obstruction

NCT07084441 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 550

Last updated 2026-05-07

No results posted yet for this study

Summary

The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.

Conditions

  • Adhesive Small Bowel Obstruction

Interventions

DRUG

Dexamethasone

\*Please see description for dexamethasone + supportive care arm.

OTHER

Supportive Care

\*Please see description for supportive care arm.

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • University of Washington

    lead OTHER

Principal Investigators

  • David Flum, MD MPH · University of Washington

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-03
Primary Completion
2030-06-30
Completion
2030-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07084441 on ClinicalTrials.gov