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Effect of Ultra-Low Tidal Volume on Mechanical Power During Heart Bypass Surgery

NCT07073885 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-03-02

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate whether ultra-low tidal volume (ULTV) ventilation during cardiopulmonary bypass (CPB) can reduce mechanical power (MP) and improve postoperative respiratory outcomes in adult patients undergoing elective coronary artery bypass graft (CABG) surgery.

The main questions it aims to answer are:

Does ULTV ventilation during CPB result in lower intraoperative mechanical power compared to apnea?

Can ULTV ventilation reduce extubation time and ICU (Intensive Care Unit) stay and improve the PaO₂/FiO₂ ratio (Partial Pressure of Arterial Oxygen / Fraction of Inspired Oxygen Ratio)?

Researchers will compare patients receiving ULTV ventilation to those undergoing apnea after aortic cross-clamping to assess the effects on mechanical power and postoperative outcomes.

Participants will:

Be randomized to either ULTV ventilation or apnea group

Undergo standard general anesthesia and CABG surgery

Have mechanical power measured at three time points (pre-CPB, post-CPB, and ICU pre-extubation)

Have arterial blood gases evaluated for PaO₂/FiO₂ ratios

Be monitored for extubation time and ICU length of stay

This study aims to generate evidence that could inform safer and more protective intraoperative ventilation strategies during cardiac surgery.

Conditions

Interventions

OTHER

Ultra-Low Tidal Volume Ventilation

Ventilation continued during CPB using volume-controlled mode with ultra-low tidal volume (3-4 mL/kg IBW(Ideal Body Weight)), 12-15 breaths/min, 5 cm H₂O PEEP, and 50% FiO₂.

OTHER

Apnea Group

In this group, mechanical ventilation will be discontinued after aortic cross-clamping during CPB, and apnea will be maintained throughout the bypass period.

Sponsors & Collaborators

  • Konya City Hospital

    lead OTHER

Principal Investigators

  • Esma karaarslan, MD · Konya City Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-10
Primary Completion
2026-02-15
Completion
2026-02-20

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07073885 on ClinicalTrials.gov