Study on Predicting Response to Standard First-Line Treatment in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Using ctDNA Combined With PET
NCT07070648 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300
Last updated 2025-07-17
Summary
This is a prospective, multicenter, multi-cohort study of ctDNA combined with PET for predicting the efficacy of standard first-line therapy for patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).
Conditions
- Diffuse Large B-Cell Lymphoma
- DLBCL
Interventions
- DRUG
-
POLA-R-CHP
Pola-R-CHP treatment for 6 cycles (IPI score 2-5)
Sponsors & Collaborators
-
Fudan University
lead OTHER
Principal Investigators
-
Rong Tao, M.D · Fudan University
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-05-09
- Primary Completion
- 2026-12-30
- Completion
- 2027-12-30
Countries
- China
Study Locations
More Related Trials
-
Combining Intratumoral Metabolic Heterogeneity and Dissemination Feature (Dmax) on 18F-FDG PET/CT Improves Prognosis Prediction in DLBCL
NCT05113576 ·Status: COMPLETED
-
CD70-targeted immunoPET Imaging of Malignant Cancers
NCT06852638 ·Status: RECRUITING ·Phase: PHASE2
-
The Value of PET Imaging Targeting Granzyme B in Predicting Efficacy and Prognosis in T-NK Cell Lymphoma
NCT06863441 ·Status: NOT_YET_RECRUITING
-
Positron Emission Tomography (PET)-Scan in the Evaluation of High Tumor Burden Follicular Lymphoma
NCT00915096 ·Status: COMPLETED
-
PET/CT-Based Image Analysis and Machine Learning of Hypermetabolic Pulmonary Lesions
NCT06602674 ·Status: COMPLETED
-
FDG-PET/CT Imaging as Early Predictor of DP
NCT02476734 ·Status: COMPLETED
-
Optimization of 18F-FDG PET/CT Response Assessment and Prognostic Evaluation Strategies for High-Metabolism Lymphoma
NCT06795113 ·Status: RECRUITING
-
Positron Nuclide Labeled NOTA-FAPI PET Study in Lymphoma
NCT04367948 ·Status: UNKNOWN ·Phase: NA
-
18F-FDG PET/CT-based Prognostic Model for Predicting Outcome in Patients With Peripheral T-cell Lymphoma
NCT03051581 ·Status: UNKNOWN ·Phase: NA
-
Safety Study of 89Zr-Anti-CLDN18.2 mAbs PET Imaging in Patients With CLDN18.2 Positive Solid Tumors
NCT04989010 ·Status: UNKNOWN ·Phase: NA
-
18F-FDG PET Radiomics of Diffuse Large B-cell Lymphoma
NCT04317313 ·Status: COMPLETED
-
PET/CT Imaging of Angiogenesis in Lung or Head and Neck Cancers Prior or During Chemotherapy With Antiangiogenic Agents
NCT02325349 ·Status: TERMINATED ·Phase: PHASE2
-
Comparison of Whole-body MRI, Circulating DNA and PET-CT in Staging, Prognosis, and Treatment Response in Patients with Diffuse Large Cell B Lymphoma
NCT06777290 ·Status: COMPLETED
-
Prediction of 18F-FES-PET/CT Parameters on Palbociclib Combined With ET
NCT04992156 ·Status: COMPLETED
-
18F-mFBG PET Imaging in the Evaluation of Neuroblastoma
NCT06852807 ·Status: RECRUITING
-
Detection and Quant of Differences in Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma Using Positron Emission Tomography/Computed Tomography (PET/CT)
NCT01004718 ·Status: COMPLETED ·Phase: NA
-
Detection and Characterization of Residual Masses in Lymphomas
NCT02300402 ·Status: COMPLETED
-
The Prognostic Value of Interim PET/CT After 2 Cycles of Chemotherapy in Predicting Progression of Non Hodgkins Lymphoma
NCT00498667 ·Status: WITHDRAWN
-
PET/CT Vs Bone Marrow Biopsy in Exclusion of Bone Marrow Infiltration for Initial Staging of Lymphoma
NCT05565898 ·Status: NOT_YET_RECRUITING
-
18F-FAPI PET/CT in Patients With Various Types of Cancer
NCT05810324 ·Status: UNKNOWN ·Phase: NA
-
18F-FDG PET Scan and MRI Diffusion.Evaluation of the Early Therapeutic Response of Diffuse Large B-cell Lymphoma
NCT03121456 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
CT and MRI in Prediction of Response in Patients With Gastric Cancer Following Neoadjuvant Chemotherapy and/or Immunotherapy
NCT04913896 ·Status: UNKNOWN
-
FDG-PET-Stratified R-DICEP and R-Beam/ASCT For Diffuse Large B-Cell Lymphoma
NCT00530179 ·Status: COMPLETED ·Phase: NA
-
Treatment of Primary CNS Lymphoma ( FTD )
NCT05274139 ·Status: COMPLETED ·Phase: PHASE2
-
Early Evaluation of the Response of Large B Cell Non Hodgkin's Lymphoma to Chemotherapy by PET/CT
NCT00256490 ·Status: COMPLETED ·Phase: NA