Prehabilitation With Aerobic and Resistance Exercise for Improving Physical Fitness and Quality of Life Outcomes in Older Patients Undergoing CAR-T Therapy for Relapsed or Refractory Multiple Myeloma

Summary

This clinical trial evaluates whether prehabilitation with aerobic and resistance exercise improves physical fitness and quality of life outcomes in older patients planning to undergo chimeric antigen receptor (CAR)-T therapy for multiple myeloma that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory). CAR-T therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. Large numbers of the CAR-T cells are grown in the laboratory and given to the patient by infusion for treatment of certain cancers. While CAR-T therapy is commonly used to treat multiple myeloma, it can result in toxicities that lead to hospitalization, nerve and muscle impairment, and decreased physical function. Prehabilitation programs use targeted interventions to improve functional status prior to medical or surgical treatments. In this study, patients participate in personalized aerobic and resistance prehabilitation activities in the weeks leading up to their CAR-T infusion. This program may improve physical fitness and quality of life, both prior to and after CAR-T infusion, in older patients with relapsed or refractory multiple myeloma.

Conditions

• Recurrent Multiple Myeloma
• Refractory Multiple Myeloma

Interventions

PROCEDURE

Accelerometry

Ancillary studies

OTHER

Aerobic Exercise

Participate in aerobic training program

PROCEDURE

Biospecimen Collection

Undergo collection of blood and urine samples

OTHER

Electronic Health Record Review

Ancillary studies

OTHER

Exercise Counseling

Receive health coaching check-in calls

OTHER

Internet-Based Intervention

Use Connected mHealth app

OTHER

Interview

Ancillary studies

OTHER

Physical Performance Testing

Ancillary studies

OTHER

Resistance Training

Participate in resistance training program

OTHER

Survey Administration

Ancillary studies

PROCEDURE

Tailored Intervention

Receive personalized exercise plan

Sponsors & Collaborators

• Mayo Clinic

  lead OTHER

Principal Investigators

• Nadine H. Abdallah, MD · Mayo Clinic

• Diane K. Ehlers, PhD · Mayo Clinic

Study Design

Allocation

NA

Purpose

SUPPORTIVE_CARE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-08-18

Primary Completion

2026-09-15

Completion

2026-09-15

Countries

• United States

Study Locations