Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness

Summary

The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.

Conditions

• Alzheimer Disease
• Aging
• Lifestyle Factors
• Cognitive Impairment
• Yoga
• Time Restricted Eating
• Diet Modification

Interventions

BEHAVIORAL

Mindfulness Yoga

A structured 9-month program integrating physical yoga postures (asanas), breathing techniques, sound, and meditation. Sessions are conducted twice weekly (90 minutes each) and focus on enhancing physical health, stress regulation, and cognitive performance. Delivered by certified instructors.

BEHAVIORAL

Time-Restricted Eating with nutritional counseling promoting a flexitarian dietary pattern

Participants follow a 16:8 time-restricted eating schedule (16 hours fasting / 8 hours eating window) for 9 months, with nutritional counseling promoting a flexitarian dietary pattern. The intervention is designed to support metabolic health and reduce risk factors for neurodegeneration.

BEHAVIORAL

Cognitive Training

A 9-month structured program of twice-weekly cognitive training sessions (90 minutes each), targeting memory, attention, executive function, and social cognition using both paper-based and computer-based tasks. Supervised by trained therapists.

BEHAVIORAL

Stretching

A twice-weekly stretching routine performed over 9 months (90-minute sessions), led by physiotherapists. This intervention provides low-intensity physical activity to control for physical engagement across study arms.

Sponsors & Collaborators

• Slovak Academy of Sciences

  collaborator OTHER_GOV

• St. Anne's University Hospital Brno, Czech Republic

  lead OTHER

Principal Investigators

• Kateřina Sheardova, MD. PhD. · The International Clinical Research Center of St. Anne's University Hospital in Brno (FNUSA-ICRC)

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-11-01

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• Czechia

Study Locations