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Fatigue in Multiple Sclerosis and Its Relationship to Inflammatory and Neurodegenerative Markers of the Disease

NCT07025122 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-06-17

No results posted yet for this study

Summary

The study is focused on several independent quantifiable biomarkers (sNfL, sGFAP, mitochondrial activity, genetics and fatigue tests) to obtain more detailed information about MS and its progression. Based on the results, investigator will further attempt to predict the course of the disease and manage the therapy more effectively to prevent worsening of the patient's condition.

Conditions

  • Fatigue in Multiple Sclerosis
  • Multiple Sclerosis
  • Neurofilaments Light Chains
  • GFAP
  • HLA DRB 1501
  • BCL6 (rs969625)
  • OS9 (rs701006)

Sponsors & Collaborators

  • Comenius University

    collaborator OTHER

  • University Hospital, Martin

    lead OTHER

Principal Investigators

  • Petra Hnilicová, PhD Ing · Comenius University

  • Ema Kantorová, prof MD PhD · UHMartin and Comenius University

  • Martin Kolísek, assoc.prof RNDr, Dr.rer.nat. · Comenius University

  • Štefan Sivák, prof.MD, PhD · UHMartin and Comenius University

  • Natália Huňarová, Mgr, doctorand · Comenius University

  • Andrea Ižarik Verešpejová, Mgr, doctorand · Comenius University

  • Daniel Čierny, associate prof, MD, PhD · UHMartin and Comenius University

  • Vladimír Nosáľ, associate prof, MD, PhD · UHMartin, Comenius University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-26
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • Slovakia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07025122 on ClinicalTrials.gov