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Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests

NCT07015359 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2025-06-11

No results posted yet for this study

Summary

Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes mellitus, renovascular disease and congestive heart failure. Mean arterial pressure (MAP) below 55-60 mmHg has been associated with postoperative AKI. Traditional diagnostic criteria for AKI include increased serum creatinine levels and oliguria. However, creatinine levels do not rise until more than half of renal function is lost. Serum and urine NGAL levels rise earlier-within 24-48 hours-making it a promising early biomarker.

In our study, hypotension is defined as systolic blood pressure \<100 mmHg or a \>30% decrease in MAP. Patients requiring ephedrine under these conditions will be evaluated as the hypotension group and compared with non-hypotensive patients in terms of NGAL, BUN (blood urea nitrogen), creatinine, and GFR (Glomerular Filtration Rate) values at baseline and at the 4th postoperative hour.

Conditions

  • Anesthesia
  • Spinal Aneshtesia
  • Acute Kidney Failure
  • Spinal Anesthesia Induced Hypotension
  • Preeclampsia (PE)

Sponsors & Collaborators

  • Ankara City Hospital Bilkent

    collaborator OTHER

  • Nihan Aydin Guzey

    lead OTHER

Principal Investigators

  • Nihan Aydın Güzey · Ankara City Hospital Bilkent

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-08
Primary Completion
2025-09-22
Completion
2025-10-20

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07015359 on ClinicalTrials.gov