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VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle

NCT07000708 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2025-09-18

No results posted yet for this study

Summary

The aim of this study is to investigate the effects of a four-week time-restricted eating (TRE) intervention on autophagy, immune function, and vaccine response to a seasonal influenza and COVID-19 vaccines in older healthy subjects.

Conditions

  • Vaccination
  • Immunosenescence
  • Metabolism

Interventions

BEHAVIORAL

TRE: Time-restricted eating

The daily eating pattern is reduced to 8 h/day. The first meal will be before 10:00 AM.

Sponsors & Collaborators

  • Max Delbrück Center for Molecular Medicine (MDC), Berlin

    collaborator UNKNOWN

  • Labor Berlin, Germany

    collaborator UNKNOWN

  • Experimental & Clinical Research Center Berlin

    collaborator UNKNOWN

  • University of Oxford

    collaborator OTHER

  • University of Cologne

    collaborator OTHER

  • Charite University, Berlin, Germany

    lead OTHER

Principal Investigators

  • Sebastian Hofer, Dr. rer. nat. · Clinical Research Unit, Experimental and Clinical Research Center, Charité, Berlin, Germany & Max-Delbrück Center for Molecular Medicine, Berlin, Germany

  • Anna Katharina Simon, Prof. Dr. · Max-Delbrück Center for Molecular Medicine, Berlin, Germany

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-10
Primary Completion
2026-09-30
Completion
2027-01-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07000708 on ClinicalTrials.gov