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Quadriceps Motor Unit Adaptation to Simulated Knee Injury

NCT06999057 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-05-01

No results posted yet for this study

Summary

This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.

Conditions

  • Muscle Inhibition
  • Knee Injury Simulation

Interventions

DEVICE

Joint Effusion via 60 mL Sterile Saline

Injection of sterile saline into the knee joint to simulate joint swelling and induce quadriceps inhibition.

DRUG

Intra-articular Lidocaine

Injection of 7 mL lidocaine into the knee joint to simulate deafferentation by temporarily blocking sensory input.

OTHER

Sham injection

Simulated knee injection using a stage needle without skin penetration, used to blind participants and serve as control.

Sponsors & Collaborators

  • University of Central Florida

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2027-08-01
Completion
2027-08-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06999057 on ClinicalTrials.gov