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Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

NCT03209531 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2025-11-26

No results posted yet for this study

Summary

The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved through a form of mental coaching and encouragement, known as operant conditioning.

Conditions

  • Anterior Cruciate Ligament Injury

Interventions

BEHAVIORAL

Control

Absence of active encouragement and feedback to increase motor evoked response when stimulated.

DEVICE

Single Pulse Transcranial Magnetic Stimulation

Transcranial magnetic stimulation to elicit a motor evoked response from the quadriceps muscles.

BEHAVIORAL

Operant Conditioning

Active encouragement and feedback to increase motor evoked response when stimulated.

Sponsors & Collaborators

  • Medical University of South Carolina

    collaborator OTHER

  • National Center of Neuromodulation for Rehabilitation

    collaborator OTHER

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    collaborator NIH

  • University of Michigan

    lead OTHER

Principal Investigators

  • Chandramouli Krishnan, PhD · Assistant Professor

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-21
Primary Completion
2025-11-24
Completion
2025-11-24

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03209531 on ClinicalTrials.gov