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Patient-Centric Study to Assess the Impact of Genomic Profiling on the Treatment of Patients With Metastatic Breast Cancer in Spain

NCT06991946 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2025-05-28

No results posted yet for this study

Summary

HOPE Focus is an observational study that aims at promoting research against metastatic breast cancer by means of collective research led by patients (patient-centric trial). Patients with metastatic breast cancer living in Spain will voluntarily register and fulfil their journey in the study through the study's digital tool. Mainly they are prompted to answer questionnaires about their disease and expectations, and to provide a blood sample and an archival tumor biopsy. In HOPE Focus these samples will be genomically analyzed and every patient case will be presented in a multidisciplinary molecular advisory board (MAB). The MAB will issue a plain report explaining the significance of the results and will enumerate future therapeutic options that match patient history and his genomic profile, when feasible. Finally, patients will have to answer short follow-up questionnaires twice a year for 3 years.

The study data will allow us to advance implementing precision medicine to improve the management of current and specially future metastatic breast cancer patients.

Conditions

Interventions

GENETIC

Liquid Biopsy

Patients with metastatic breast cancer in disease progression will undergo a liquid biopsy

GENETIC

Archival Tumor DNA

Patients will be prompted to request an archival tumor sample from metastatic origin (preferably) and to send it to the central laboratory for analysis

Sponsors & Collaborators

  • Roche Farma, S.A

    collaborator INDUSTRY

  • Menarini Group

    collaborator INDUSTRY

  • AstraZeneca

    collaborator INDUSTRY

  • Pfizer

    collaborator INDUSTRY

  • Eli Lilly and Company

    collaborator INDUSTRY

  • SOLTI Breast Cancer Research Group

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-20
Primary Completion
2027-05-20
Completion
2030-05-20

Countries

  • Spain

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06991946 on ClinicalTrials.gov