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Lipid Emulsion for Reversal of Spinal Anesthesia in Ambulatory Surgery

NCT06988982 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2025-05-25

No results posted yet for this study

Summary

Ambulatory surgery places high demands on anesthetic technique. rapid onset and offset of anesthesia, rapid recovery of protective reflexes, mobility and micturition, are required. Since the inception of ambulatory surgery, the favored anesthetic technique has been general anesthesia with short-acting drugs. Concerns about the time to perform spinal anesthesia and the risks of prolonged motor block and urinary retention have limited its use.

Alpha-blockers, lavage fluids for epidural space, insulin, and intravenous lipid emulsions, are still being discussed to shorten and reverse adverse effect of different LAs used for spinal anaesthesia, hence we will evaluate the effectiveness of intravenous lipid emulsion for reversing the neural blockade of spinal anaesthesia in patients undergoing ambulatory surgery.

Conditions

  • Spinal Anaesthesia
  • Spinal Anesthesia Evaluation
  • Ambulatory Surgery

Interventions

DRUG

Intravenous Lipid Emulsion 20%

patients will receive 1.5 ml/kg bolus of intravenous lipid emulsion 20 % followed by 0.25 ml/kg/hr infusion over 30 minutes at the end of surgery

DRUG

Control (placebo) group

patients will receive equal volume of normal saline at the end of surgery

Sponsors & Collaborators

  • Zagazig University

    lead OTHER_GOV

Principal Investigators

  • Sherif M. S. Mowafy, MD · Anaesthesia, Intensive Care, and Pain Management Department. Faculty of Medicine, Zagazig University,

  • Shereen E. Abd Ellatif, MD · Anaesthesia, Intensive Care, and Pain Management Department. Faculty of Medicine, Zagazig University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2025-12-30
Completion
2026-01-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06988982 on ClinicalTrials.gov