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Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery

NCT06988176 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-01-28

No results posted yet for this study

Summary

The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.

The main questions it aims to answer are:

* Do measures of frailty and muscle strength, taken before surgery, predict complications after surgery?
* Can these tests be easily done during a routine pre-surgical visit?

Participants will:

* Complete brief tests measuring muscle strength, breathing strength, physical function, nutrition status, body composition, and memory during a regular pre-surgical clinic appointment.
* Allow researchers to review their medical records 30 and 90 days after surgery to identify any complications or health problems.

Conditions

  • Frailty
  • Sarcopenia
  • Sarcopenia in Elderly
  • Muscle Strength
  • Post Operative Complications
  • Nutrition Assessment
  • Risk Assessment
  • Elderly (People Aged 65 or More)
  • Hand Strength

Interventions

DIAGNOSTIC_TEST

Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing

Participants will undergo a structured frailty and muscle-strength assessment battery performed during their routine preoperative evaluation. These assessments serve as the primary exposure measures of interest and include: Clinical Frailty Scale (CFS) evaluation (functional frailty assessment) Respiratory muscle strength assessment (Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP) using a MicroRPM handheld respiratory pressure meter) Hand-grip strength measurement (using Jamar dynamometer) Physical performance evaluation (Timed Up-and-Go (TUG) test) Skeletal muscle mass estimation (Bioelectrical impedance analysis, InBody 120) Muscle thickness measurement (Rectus femoris muscle thickness using portable ultrasound) Cognitive function screening (Mini-Cog test) Nutritional risk screening (Perioperative Nutrition Screen \[PONS\]) No additional interventions beyond these observational assessments will be conducted.

Sponsors & Collaborators

  • University of North Carolina, Chapel Hill

    lead OTHER

Principal Investigators

  • Monika Nanda, MBBS, MPH, FASA · University of North Carolina, Chapel Hill

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-19
Primary Completion
2026-06-30
Completion
2026-08-31

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06988176 on ClinicalTrials.gov