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Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)

NCT06988111 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2026-04-30

No results posted yet for this study

Summary

Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations. Traditional escalation often involves invasive mechanical ventilation, which is associated with ventilator-associated pneumonia (VAP), prolonged intensive care unit (ICU) stays, and increased resource burden.

Conditions

  • Respiratory Failure Without Hypercapnia
  • Respiratory Failure With Hypercapnia
  • Postoperative Respiratory Complication

Interventions

DEVICE

BIPAP

The second arm (NIV group) will be managed by BIPAP device for post-operative respiratory failure

DEVICE

Vapotherm

The first arm (HVNC group) will be managed by Vapotherm device for post-operative respiratory failure

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Ahmad M. Shaddad, MD · Assuit Univeristy

  • Aliae A. Hussien, MD · Assiut University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2026-07-01
Completion
2026-12-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06988111 on ClinicalTrials.gov