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The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

NCT06983730 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2026-02-05

No results posted yet for this study

Summary

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are:

* How do the chemicals produced by the body change under conditions of higher versus lower heat stress?
* What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

Conditions

  • Heat Strain
  • Healthy Volunteer Study
  • Kidney Dysfunction

Interventions

DIETARY_SUPPLEMENT

Vitamin B3

1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session.

Sponsors & Collaborators

  • Boston University Charles River Campus

    collaborator OTHER

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • Beth Israel Deaconess Medical Center

    lead OTHER

Principal Investigators

  • Nathan H Raines, MD MPH · Beth Israel Deaconess Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-26
Primary Completion
2028-06-30
Completion
2028-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06983730 on ClinicalTrials.gov