Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance

Summary

From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations. However, colonoscopy is burdensome for patients and colonoscopy availability is limited in many parts of the world. In addition, more than half of surveillance colonoscopies are without any findings. The trial investigates whether surveillance using fecal testing for blod is as good as colonoscopy after removal of colorectal polyps.

Conditions

• Colorectal Neoplasms

Interventions

DIAGNOSTIC_TEST

Fecal occult blood testing

Fecal testing for blood as surveillance efter polyp removal

DIAGNOSTIC_TEST

Colonoscopy

Colonoscopy after polyp removal according to guidelines

Sponsors & Collaborators

• Sykehuset Ostfold

  collaborator OTHER

• University Hospital, Akershus

  collaborator OTHER

• Vestre Viken Hospital Trust

  collaborator OTHER

• Sykehuset Telemark Hospital Trust

  collaborator UNKNOWN

• Helse Møre og Romsdal HF

  collaborator OTHER_GOV

• St. Olavs Hospital

  collaborator OTHER

• University Hospital of Northern Norway, Tromsø, Norway

  collaborator UNKNOWN

• Sykehuset i Vestfold HF

  collaborator OTHER

• Helse Stavanger HF

  collaborator OTHER_GOV

• Turku University Hospital

  collaborator OTHER_GOV

• Helsinki University Central Hospital

  collaborator OTHER

• Randers Regional Hospital

  collaborator OTHER

• Viborg Regional Hospital

  collaborator OTHER

• Gødstrup Hospital

  collaborator OTHER

• Horsens Hospital

  collaborator OTHER

• Sorlandet Hospital HF

  lead OTHER_GOV

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-01-09

Primary Completion

2040-12-31

Completion

2050-01-01

Countries

• Norway

Study Locations