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Current Microsatellite Stability Results in Colon Cancer

NCT06971107 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 1500

Last updated 2025-05-14

No results posted yet for this study

Summary

The goal of this prospective observational study is to learn more about how a specific type of DNA repair issue-called mismatch repair deficiency (dMMR)-affects colon cancer in people living in Turkey. The study will look at how often dMMR occurs, how it is reported, and how it relates to treatment outcomes.

The main questions it aims to answer are:

* How common is dMMR in colon cancer, and does it vary by where the tumor is in the colon?
* How often is MSI (microsatellite instability) status reported in colon cancer biopsy reports before surgery?
* How do different types of dMMR (such as MLH1/PMS2 loss, MSH2/MSH6 loss, or sporadic cases) affect survival over three years?

Participants will:

* Be people who had surgery for colon cancer between June 1, 2025 and May 31, 2026 at hospitals in Turkey that treat more than 30 colon cancer cases each year.
* Have their medical and pathology data reviewed, including information about tumor location, biopsy results, surgery, and treatment.

This study will not involve any new treatments. Instead, it will use existing medical records to better understand how to improve care and identify people who may benefit from immunotherapy. Results from this study will be shared at scientific meetings and published in medical journals.

Conditions

  • Colon Adenocarcinoma
  • MSI Positive Colorectal Cancer
  • MSI Negative Colorectal Cancer

Sponsors & Collaborators

  • Turkish Society of Colon and Rectal Surgery

    lead OTHER

Principal Investigators

  • Ahmet Rencüzoğulları, Professor · Koç University

  • Mustafa Öncel, Professor · İstanbul Medipol University

  • Burak Yavuz, M.D. · Republic of Türkiye Ministry of Health Kozan State Hospital

  • Atıf Tekin, M.D. · İstanbul Medipol University

  • Cihangir Akyol, Professor · Ankara University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2026-05-31
Completion
2029-05-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06971107 on ClinicalTrials.gov