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Use of Endotracheal Tube Cuff Pressure to Assess Inspiratory Effort During Pressure Support Ventilation

NCT06968793 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-01-21

No results posted yet for this study

Summary

During pressure support ventilation (PSV), monitoring of Esophageal Pressure (Pes) has long been considered the gold standard for assessing intrathoracic pressure and the state of respiratory mechanics.The aim of this study was to investigate the correlation between Cuff Pressure (Pcuff) and Esophageal Pressure in patients undergoing tracheal intubation or tracheotomy, and to assess whether Pcuff can be used as a surrogate for Pes for reflecting changes in intrathoracic pressure.The correlation and its consistency between the two under different ventilation conditions were analysed by synchronously monitoring the ΔPcuff and ΔPes to further validate the potential application value of cuff pressure in clinical practice.The results of the study will provide a more convenient and non-invasive method of monitoring intrathoracic pressure in mechanically ventilated patients, thus optimising ventilation strategies, reducing complications, and promoting the innovation and development of monitoring technology in the field of critical care medicine.

Conditions

  • Mechanical Ventilation
  • Critical Care
  • Inspiratory Effort

Interventions

PROCEDURE

Pressure support 15

Pressure support of 15 cm H2O will be applied for 5 minutes.

PROCEDURE

Pressure support 13

Pressure support of 13 cm H2O will be applied for 5 minutes.

PROCEDURE

Pressure support 11

Pressure support of 11 cm H2O will be applied for 5 minutes.

PROCEDURE

Pressure support 9

Pressure support of 9 cm H2O will be applied for 5 minutes.

PROCEDURE

Pressure support 7

Pressure support of 7 cm H2O will be applied for 5 minutes.

PROCEDURE

Pressure support 5

Pressure support of 5 cm H2O will be applied for 5 minutes.

Sponsors & Collaborators

  • Jian-Xin Zhou

    lead OTHER

Principal Investigators

  • Jian-Xin Zhou, MD, PhD · Capital Medical University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-20
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06968793 on ClinicalTrials.gov