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Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

NCT06965023 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2025-05-11

No results posted yet for this study

Summary

Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.

Conditions

  • ST-elevation Myocardial Infarction (STEMI)
  • Microplastics
  • Nanoplastics
  • Pollution Exposure

Sponsors & Collaborators

  • University of Campania Luigi Vanvitelli

    collaborator OTHER

  • Azienda Ospedaliera Universitaria Integrata Verona

    collaborator OTHER

  • Morgagni Pierantoni Hospital

    collaborator OTHER

  • Azienda Ospedaliera Sant'Anna e San Sebastiano

    collaborator OTHER

  • University Hospital, Catania

    collaborator OTHER

  • A.O.U. Città della Salute e della Scienza - Molinette Hospital

    collaborator OTHER

  • Niguarda Hospital

    collaborator OTHER

  • Azienda Ospedaliera Universitaria Ferrara

    collaborator UNKNOWN

  • Azienda Ospedaliera "Sant'Andrea"

    lead OTHER

Principal Investigators

  • Pasquale Paolisso, MD, PhD · Sant'Andrea University Hospital

  • Marta Belmonte, MD · Sant'Andrea University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-22
Primary Completion
2026-12-30
Completion
2027-12-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06965023 on ClinicalTrials.gov