QL1706 Plus Chidamide, AG as First-line Treatment for Metastatic Pancreatic Cancer
NCT06951997 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 33
Last updated 2026-01-26
Summary
This is a single-center, open-label, exploratory study aims to assess the efficacy and safety of QL1706 plus nab-paclitaxel and gemcitabine as first-line treatment for patients with metastatic pancreatic adenocarcinoma.
Conditions
Interventions
- DRUG
-
QL1706
5mg/kg, q3w
- DRUG
-
Chidamide
20mg, biw, q3w
- DRUG
-
1000mg/m2 Q3W
- DRUG
-
125mg/m2 Q3W
Sponsors & Collaborators
-
Tianjin Medical University Cancer Institute and Hospital
lead OTHER
Principal Investigators
-
Rui Liu · Tianjin Medical University Cancer Institute and Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-03-07
- Primary Completion
- 2027-05-15
- Completion
- 2027-12-31
Countries
- China
Study Locations
More Related Trials
-
Chemo4METPANC Combination Chemokine Inhibitor, Immunotherapy, and Chemotherapy in Pancreatic Adenocarcinoma
NCT04543071 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Compare QLS31905 and Chemotherapy With Placebo and Chemotherapy in Participants With Pancreatic Cancer
NCT07079228 ·Status: RECRUITING ·Phase: PHASE3
-
SHR- 1210 Combined With Paclitaxel (Albumin Bound) and Gemcitabine as First-line Therapy in Patients With Metastatic Pancreatic Cancer
NCT04181645 ·Status: COMPLETED ·Phase: NA
-
Study of Immunotherapy Combined With Chemotherapy in Locally Advanced and Metastatic Pancreatic Cancer
NCT04324307 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Efficacy and Safety of Camrelizumab Combined With Nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer
NCT04498689 ·Status: UNKNOWN ·Phase: PHASE2
-
Cadonilimab Combined With S-1 or Capecitabine as Second-line Treatment for Advanced Pancreatic Cancer
NCT06532617 ·Status: RECRUITING ·Phase: PHASE2
-
Irinotecan Liposome,Albumin Paclitaxel and Gemcitabine First-line Treatment for Pancreatic Cancer
NCT06513455 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Iparomlimab and Tuvonralimab Combined With GC in Advanced ICC
NCT07152769 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
An Open-label, Phase I/II Study of the Pan-immunotherapy in Patients With Local Advanced/Metastatic Pancreatic Cancer
NCT03989310 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Radiotherapy to Patients With CA19-9-elevated Advanced Pancreatic Cancer
NCT06250972 ·Status: RECRUITING ·Phase: PHASE3
-
Influence Factors of PD-1 Therapeutic Efficacy in Advanced Pancreatic Cancer
NCT05201729 ·Status: UNKNOWN
-
Albumin-Bound Paclitaxel and Gemcitabine With or Without S-1 as First-Line Treatment for Advanced Pancreatic Cancer
NCT06789679 ·Status: RECRUITING ·Phase: PHASE2
-
Decitabine Combined With Gemcitabine in First-line Treatment of AdvancedPancreatic Cancer
NCT02685228 ·Status: UNKNOWN ·Phase: NA
-
Pembrolizumab Plus Chemotherapy in 1st Line Treatment of Pancreatic Cancer
NCT04447092 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Anlotinib Plus PD-1 Inhibitor as 2nd-line Threapy in Patients With Metastatic Pancreatic Cancer
NCT05218629 ·Status: UNKNOWN ·Phase: PHASE2
-
Oncolytic Virus Plus PD-1 Inhibitor to Patients With Advanced Pancreatic Cancer
NCT06196671 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Clinical Study of Multimodal Ablation Remodeling Immunosensitized PD-1 in the Treatment of Pancreatic Cancer With Liver Metastasis
NCT06307080 ·Status: RECRUITING ·Phase: NA
-
QUILT-2.019: A Study of AMG 655 or AMG 479 in Combination With Gemcitabine for Treatment of Metastatic Pancreatic Cancer
NCT00630552 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Clinical Trial for Advanced or Metastatic Pancreatic Cancer
NCT06255912 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
The Safety and Efficacy of Specific TIL-TCM Cells for Advanced Relapse-refractory or Metastatic Pancreatic Cancer
NCT05438797 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Active Anti-diabetic Treatment Plus Chemotherapy for Pancreatic Cancer Related Diabetes
NCT07272109 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
A Study of MR001 Combined With Chemotherapy in Patients With Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) After First-line Therapy
NCT07235202 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Efficacy and Safety of Paclitaxel Liposome and S-1 as First-line Therapy in \ Advanced Pancreatic Cancer Patients
NCT04217096 ·Status: UNKNOWN ·Phase: PHASE4
-
A Phase II Randomized Study of Gemcitabine and Nab-paclitaxel in Combination With S- 1/LV (GASL) or Oxaliplatin (GAP) as First-line Treatment for Metastatic Pancreatic Cancer
NCT05026905 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Trilaciclib Combined With mFOLFIRINOX in the Treatment of Patients With Advanced Pancreatic Cancer
NCT06151262 ·Status: RECRUITING ·Phase: PHASE2