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Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked

NCT06944639 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-02-17

No results posted yet for this study

Summary

This study is being done to compare how quickly three different types of collagen membranes break down when they are exposed to the mouth. These membranes are often used in dental and oral surgery to help with healing and tissue growth. The goal is to find out if one membrane lasts longer than the others, which may help doctors choose the best option for different procedures.

In this study, the membranes will be placed in the mouth in a specific area near the gums of the upper back teeth. The study is designed so that neither the patients nor the researchers evaluating the results will know which membrane is which (this is called a double-blind study). Over time, researchers will measure how much each membrane has broken down. This information may help improve treatment planning and patient outcomes in dental care.

Conditions

  • Bone Regeneration

Interventions

DEVICE

Membrane Jason MB GmbH Non-cross-linked (NCL)

The membrane will be stabilized in the oral mucosa using sutures and flowable composite.

DEVICE

Membrane BioMend Extend Glutaraldehyde cross-linked

The membrane will be stabilized in the oral mucosa using sutures and flowable composite.

DEVICE

Membrane OSSIX Agile Ribose cross-linked (RCL)

The membrane will be stabilized in the oral mucosa using sutures and flowable composite.

Sponsors & Collaborators

  • Dentsply Sirona Inc.

    collaborator INDUSTRY

  • Andrea Ravida

    lead OTHER

Principal Investigators

  • Andrea Ravida, DDS, MS, PhD · Program Director of the Periodontics and Implant Dentistry Department

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-28
Primary Completion
2026-07-31
Completion
2026-07-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06944639 on ClinicalTrials.gov