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Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

NCT06910969 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 350

Last updated 2026-03-03

No results posted yet for this study

Summary

The goal of this study is to demonstrate the efficacy of a multidisciplinary group-based telehealth intervention (HORIZONS) compared to minimally enhanced usual care for improving self-management and quality of life for hematopoietic stem cell transplant (HSCT) survivors living with chronic graft-versus host disease, and to identify critical facilitators and barriers for HORIZONS implementation and adoption.

Conditions

  • Bone Marrow Transplant Complications
  • Graft-versus-Host Disease

Interventions

BEHAVIORAL

HORIZONS Intervention

Therapist-delivered multidisciplinary group-based telehealth intervention comprised of 8 sessions

BEHAVIORAL

Minimally enhanced usual care

Receiving a standardized booklet with evidence-based information on chronic GHVD management and HST survivorship recommendations

Sponsors & Collaborators

  • University of Miami Sylvester Comprehensive Cancer Center

    collaborator OTHER

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Areej El-Jawahri MD · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-13
Primary Completion
2029-06-01
Completion
2030-02-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06910969 on ClinicalTrials.gov