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Comparative Outcomes of Endoscopic and Open Carpal Tunnel Release with Neurotrophic Supplementation in Severe Carpal Tunnel Syndrome

NCT06902831 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 497

Last updated 2025-03-30

No results posted yet for this study

Summary

This study addresses the pressing clinical question of optimizing surgical and pharmacological interventions for severe Carpal Tunnel Syndrome (CTS), a prevalent and debilitating condition caused by median nerve compression. Previous research has established the efficacy of Open Carpal Tunnel Release (OCTR) and Endoscopic Carpal Tunnel Release (ECTR); however, the role of neurotrophic supplementation in enhancing surgical outcomes has yet to be fully elucidated. Using a prospective clinical approach involving 497 patients, we evaluated the comparative outcomes of ECTR and OCTR with or without neurotrophic supplementation. Key findings demonstrate that ECTR, particularly when combined with neurotrophic agents, facilitates faster recovery and greater improvements in Sensory Nerve Conduction Velocity (VCS) and Visual Analog Scale (VAS) scores, with reduced complication rates compared to OCTR

Conditions

  • Carpal Tunnel Syndrome (CTS)

Interventions

PROCEDURE

Endoscopic Carpal Tunnel Release

Release of carpal tunnel with endoscopic device

PROCEDURE

Open carpal tunnel release

Release of carpal tunnel with open tecnique

DRUG

Neurotrophic supplementation

Neurotrophic supplementation after surgery

Sponsors & Collaborators

  • University of Bari

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2024-04-01
Completion
2024-04-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06902831 on ClinicalTrials.gov